Design, synthesis and antibacterial activity of novel andrographolide derivatives
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- 作者：Zhongli Wang ; Pei Yu ; Gaoxiao Zhang ; Lipeng Xu ; Dingyuan Wang ; Liang Wang ; Xiangping Zeng ; Yuqiang Wang
- 关键词：Andrographolide derivatives ; Synthesis ; Antibacterial ; Quorum sensing
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2010
- 出版时间：15 June 2010
- 年：2010
- 卷：18
- 期：12
- 页码：4269-4274
- 全文大小：400 K
文摘
A series of andrographolide derivatives were synthesized through a facile condensation reaction with different carboxylic acids. The new compounds were characterized and screened for their antibacterial activities. A number of the new compounds significantly reduced bacterial quorum sensing virulence factors production in Pseudomonas aeruginosa, essential for pathogenesis. Compound 11b showed the best activity among all the new compounds.