MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor β/δ-dependent manner
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- 作者：Kai Gong1 ; Bo Qu1 ; Dongfa Liao ; Da Liu ; Cairu Wang ; Jingsong Zhou ; Xianming Pan ; xianmingpanxj@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MiR-132 ; Sirtuin1 ; Peroxisome proliferator-activated receptor β/δ ; Osteogenic differentiation ; Diabetic osteoporosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：9 September 2016
- 年：2016
- 卷：478
- 期：1
- 页码：260-267
- 全文大小：1709 K
文摘
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MiR-132 participates in regulating osteogenic differentiation of MC3T3-E1 cells.
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Sirt1 is a target gene of miR-132.
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Sirt1 is the effector of miR-132 in regulating osteogenic differentiation.
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MiR-132-Sirt1 regulates osteogenic differentiation in a PPARβ/δ–dependent manner.