SNPs of bovine HGF gene and their association with growth traits in Nanyang cattle
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- 作者：Hanfang Cai ; Xianyong Lan ; Aimin Li ; Yang Zhou ; Jiajie Sun ; Chuzhao Lei ; Chunlei Zhang ; Hong Chen
- 关键词：Chinese cattle ; Growth traits ; HGF gene ; SNPs
- 刊名：Research in Veterinary Science
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：95
- 期：2
- 页码：483-488
- 全文大小：689 K
文摘
Hepatocyte growth factor (HGF) is one of the multifunctional cell factors that regulates cellular proliferation, motility and morphogenesis in mammalians. And its medical research has deep significance. In this paper, polymorphisms of HGF gene were investigated in 1433 health and irrelated Chinese cattle by PCR-RFLP and DNA sequencing approach. Ten novel Single nucleotide polymorphisms (SNPs) were identified, which included one missense mutation, g.72801G>A in the coding region, and the others in the intron. Association analysis between four of them, g.288T>C, g.72801G>A, g.77172G>T, and g.77408T>G, and growth traits in Nanyang, were performed. The results indicated that SNPs within bovine HGF gene were significantly associated with growth traits. Phylogenetic analysis showed that the genetic background of Caoyuan Red cattle was different from the others in the tested breeds. The findings will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.