Two new sesquiterpenes and six norsesquiterpenes from the solid culture of the edible mushroom Flammulina velutipes

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• 作者：Yaqi Wang^a ; ^b ; ^&dagger ; ; Li Bao^a ; ^&dagger ; ; Dailin Liu^c ; Xiaoli Yang^a ; Shaifei Li^a ; Hao Gao^b ; Xinsheng Yao^b ; ^{tyaoxs@jnu.edu.cn} ; Huaan Wen^a ; Hongwei Liu^a ; ^{liuhw@im.ac.cn}
• 关键词：Flammulina velutipes ; Sesquiterpenes ; Structure elucidation ; Cytotoxicity
• 刊名：Tetrahedron
• 出版年：2012
• 出版时间：8 April, 2012
• 年：2012
• 卷：68
• 期：14
• 页码：3012-3018
• 全文大小：594 K

文摘

One new sesquiterpene with a novel carbon skeleton, flammulinol A (1), one new isolactarane sesquiterpene and six isolactarane-related norsesquiterpenes, flammulinolides A-G (2-8), as well as sterpuric acid, were isolated from the solid culture of Flammulina velutipes. The structures of the new compounds were elucidated by spectroscopic methods. The absolute configuration of C-3 in 1 was determined via the circular dichroism data analysis based on the octane rule of cyclopentenone, whereas the absolute configurations of compounds 2, and 5-8 were assigned using the circular dichroism data of the [Rh₂(OCOCF₃)₄] complex. Compounds 2, 3, and 7 showed strong cytotoxicity against KB cell line with the IC₅₀ of 3.9, 3.6, and 4.7?¦ÌM, respectively. Compound 4 showed strong cytotoxicity against Hela cell line with the IC₅₀ of 3.0?¦ÌM. The plausible biosynthetic pathway for 2-9 in F. velutipes was discussed.