UPLC-Q-TOF-MSE analysis of the constituents of Ding-Zhi-Xiao-Wan, a traditional Chinese antidepressant, in normal and depressive rats
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- 作者：Lu Xua ; b ; Li-Hua Mua ; Jie Pengc ; Wan-Wan Liua ; d ; Xiao Tana ; Zhao-Liang Lia ; d ; Dong-Xiao Wanga ; Ping Liua ; liuping301@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CE ; collision energy ; CUMS ; chronic unpredictable mild stress ; DZXW ; Ding-Zhi-Xiao-Wan ; HMG ; 3-Hydroxy-3-methyl-glutaryl ; p-CREB ; abrain-derived neurotrophic factor protein ; CORT ; corticosterone ; ACTH ; adrenocorticotropic hormone ; CRH ; corticotrophin releasing hormone ; UPLC-Q-TOF-MS ; ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry ; ESI ; Electrospray ionization
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1026
- 期：Complete
- 页码：36-42
- 全文大小：1509 K
文摘
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Ding-Zhi-Xiao-Wan (DZXW) is an antidepressant used in traditional Chinese medicine.
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A UPLC-Q-TOF-MSE method was developed to analyse the constituents of DZXW.
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The metabolites of DZXW in normal and depressive rats were investigated firstly.
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Eighty-eight compounds were identified in DZXW; three were potentially novel.
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DZXW constituents involved in antidepressant effects were identified in CUMS rats.