Novel cinnamohydroxamic acid derivatives as HDAC inhibitors with anticancer activity in vitro and in vivo
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- 作者：Lihui Wanga ; b ; Xuefei Baoc ; Jingyu Yanga ; b ; Huahuan Lia ; b ; Qifan Zhouc ; Xiaorui Jianga ; b ; Meng Lia ; b ; Xing Liua ; b ; Xiangzhong Yuana ; b ; Yuhong Suna ; b ; Junli Chena ; b ; Jingyuan Zhangb ; Guoliang Chenc ; guoliang222@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Chunfu Wua ; b ; wucf@syphu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Histone deacetylase inhibitor ; Cancer ; Apoptosis ; Cell cycle
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：249
- 期：Complete
- 页码：64-70
- 全文大小：1591 K
文摘
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7e, a cinnamohydroxamic acid derivative, suppresses HDAC activity.
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7e prompts cell cycle arrest and induces cell apoptosis.
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7e inhibits tumor growth but with lower toxicity in vitro and in vivo.