CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription
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- 作者：Zhonghui Tang1 ; 12 ; Oscar Junhong Luo1 ; 12 ; Xingwang Li1 ; 2 ; 12 ; Meizhen Zheng1 ; Jacqueline Jufen Zhu1 ; 3 ; Przemyslaw Szalaj4 ; 5 ; 6 ; Pawel Trzaskoma7 ; Adriana Magalska7 ; Jakub Wlodarczyk7 ; Blazej Ruszczycki7 ; Paul Michalski1 ; Emaly Piecuch1 ; 3 ; Ping Wang1 ; Danjuan Wang1 ; Simon Zhongyuan Tian1 ; May Penrad-Mobayed8 ; Laurent M. Sachs9 ; Xiaoan Ruan1 ; Chia-Lin Wei10 ; Edison T. Liu1 ; Grzegorz M. Wilczynski7 ; Dariusz Plewczynski6 ; Guoliang Li2 ; 11 ; Yijun Ruan1 ; 2 ; 3 ; yijun.ruan@jax.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：163
- 期：7
- 页码：1611-1627
- 全文大小：9721 K
文摘
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ChIA-PET is inclusive in mapping 3D genome at multi-scale and nucleotide resolution
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CTCF foci spatially arrange RNAPII transcription concordant in CTCF-motif direction
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SNPs alter haplotype chromatin topology and function that link to disease risks
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3D genome models elucidate topological framework for transcriptional regulation