Effect of rosuvastatin on atherosclerotic plaque stability: An intravascular ultrasound elastography study
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- 作者：Zhaohuan Li1 ; Lin Wang1 ; Xiaobo Hu ; Pengfei Zhang ; Yifei Chen ; Xinxin Liu ; Mingjun Xu ; Yun Zhang ; Mei Zhang ; daixh@vip.sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rosuvastatin ; Intravascular ultrasonic elastography ; Shear strain ; Area strain ; Vulnerable plaque ; Rabbit model
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：248
- 期：Complete
- 页码：27-35
- 全文大小：2739 K
文摘
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Rosuvastatin stabilizes the mechanical properties of atherosclerotic plaques in rabbits.
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The shoulder of eccentric plaque develops faster than the body region into a rupture-prone site.
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Rosuvastatin keeps the shear and area strain of the plaque shoulder region at a low level.
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The differences in mechanical properties are related to plaque composition.
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IVUSE is a sensitive technique for detecting pharmacologically-induced mechanical changes in rabbit atherosclerotic plaques.