- 作者：Kang Zhou ; MD ; PhD ; Yangzhao Zhou ; MD ; Yuan Zhao ; MD ; PhD ; Changming Tan ; MD ; Zhaoshun Yuan ; MD ; Jianming Li ; MD ; PhD ; Xiaobo Liao ; MD ; PhD ; Lu Gu ; MD ; Xinmin Zhou ; MD ; PhD ; mark090103@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aortic stenosis ; Myocardial hypertrophy ; Galectin-3 ; Myocardial remodelling ; Fibrosis
- 刊名：Heart, Lung and Circulation
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：25
- 期：4
- 页码：371-377
- 全文大小：798 K
Methods
Galectin-3 expression was measured in the plasma and myocardia of AS patients who underwent an aortic valve replacement procedure.
Results
The study enrolled 77 consecutive patients with severe AS. Fifty-five (71.43%) of the enrolled patients had concentric hypertrophy (CH group), and had the highest degree of fibrosis (27.10 ± 5.25%; p < 0.001) and expression of Gal-3 in both plasma (19.11 ± 2.06 ng/mL) and myocardial tissue (3.01 ± 0.79). There was a strong positive correlation between the levels of fibrosis and Gal-3 expression in both plasma (r = 0.584, p < 0.001) and myocardium (r = 0.522, p < 0.001). Relative wall thickness (RWT) was strongly correlated with Gal-3 expression in both myocardium (r = 0.594, p < 0.001) and plasma (r = 0.323, p = 0.005). Additionally, N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were positively correlated with both fibrosis (r = 0.313, p = 0.036) and LV mass index (r = 0.559, p < 0.001).
Conclusions
Concentric hypertrophy geometry was the most common type of myocardium remodelling, and AS patients with CH geometry showed the highest levels of Gal-3 expression. Galectin-3 levels were positively correlated with fibrosis and RWT, both of which are crucial indicators of geometric remodelling. Galectin-3 and NT-proBNP levels may be valuable prognostic predictors in AS patients with myocardial remodelling.