文摘
In this study, the chelation of Hypocrellin A (HA) with Al3+ in water solution has been synthesized, and the interactions of HA and Al3+-HA complex with calf thymus DNA are in detail compared by UV-vis and fluorescence spectroscopic techniques, circular dichroism spectroscopy and viscosity measurement. The experiment results suggest that HA and Al3+-HA complex both could bind to CT DNA by intercalation mode, and double helix of DNA was damaged. Moreover, Al3+-HA complex not only displays higher absorption at therapeutic window but also displays stronger binding affinity to CT DNA than HA.