Study of breakthrough cancer pain in an animal model induced by endothelin-1
详细信息 查看全文
- 作者：Yixun Tanga ; Hao Penga ; Qian Liaoa ; Li Gana ; Raoxiang Zhanga ; Lihua Huangb ; Zhigang Dingb ; Hui Yanga ; Xuebin Yana ; Yonghong Guc ; Xiaofang Zangd ; Dong Huanga ; huangdong6619@vip.163.com" class="auth_mail" title="E-mail the corresponding author ; Shousong Caoe ; f ; shousongc@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ET-1 ; Endothelin-1 ; LLC ; Lewis lung carcinoma ; BTP ; breakthrough pain ; BTcP ; breakthrough cancer pain ; PID ; post-implantation day ; i.p. ; intraperitoneal
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：23 March 2016
- 年：2016
- 卷：617
- 期：Complete
- 页码：108-115
- 全文大小：1205 K
文摘
- •
We established an animal model of breakthrough cancer pain for the first time which shows high resemblance compared to the breakthrough cancer pain in human clinically.
- •
The animal model of breakthrough cancer pain was induced by endothelin-1. The selective ETA receptor antagonist BQ-123 could reverse breakthrough pain.
- •
We studied the characteristics of pain behaviors such as hind limb use score and voluntary wheel running with the model.
- •
We also studied the electrophysiology of sciatic nerve fiber in corresponding to the pain behaviors with the model.
- •
The model provides a platform for further study of the pathogenesis of breakthrough cancer pain and related targeted intervention.