The interaction of MMP-2/B7-H3 in human osteoporosis
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- 作者：Ping Fenga ; 1 ; Hong Zhanga ; 1 ; Zhuqiu Zhangb ; Xiaoli Daia ; Ting Maoa ; Yinyin Fana ; Xiaofang Xiea ; Huiyan Wena ; Peijuan Yua ; Yae Huc ; yrhzl@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Ruhong Yana ; anne_yrh@sohu.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bone ; Soluble B7-H3 ; Osteoporosis ; Matrix metalloproteinases
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：162
- 期：Complete
- 页码：118-124
- 全文大小：1346 K
文摘
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MMP-2 was positively correlated with sB7-H3 in osteoporosis patients.
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Elevated MMP-2 levels resulted in elevated sB7-H3 and reduced osteoblastic mB7-H3.
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B7-H3-deficient MG63 cells decreased osteoblastic markers and mineralized nodules.
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Membrane B7-H3 is required for the later phases of osteoblast differentiation.
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MMP-2/B7-H3 plays a negative regulatory role in osteoporosis.