Association of Brachial-Ankle Pulse Wave Velocity with Asymptomatic Intracranial Arterial Stenosis in Hypertension Patients

详细信息    查看全文

• 作者：Yan Wang ; MD ; PhD^* ; Jin Zhang ; MD^* ; Yuesheng Qain ; MD^* ; Xiaofeng Tang ; MD^* ; Huawei Ling ; MD^&dagger ; ; Kemin Chen ; MD^&dagger ; ; Yan Li ; MD^* ; Pingjin Gao ; MD^* ; Dingliang Zhu ; MD ; PhD^* ; ^{zhudingliang@sibs.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Intracranial arterial stenosis ; brachial-ankle PWV ; homocysteine ; hypertension ; Chinese population
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：25
• 期：8
• 页码：1922-1928
• 全文大小：395 K

文摘

Intracranial arterial stenosis is a common cause of ischemic stroke in Asians. We therefore sought to explore the relationship of brachial-ankle pulse wave velocity and intracranial arterial stenosis in 834 stroke-free hypertensive patients.

Methods

Intracranial arterial stenosis was evaluated through computerized tomographic angiography. Brachial-ankle pulse wave velocity was measured by an automated cuff device.

Results

The top decile of brachial-ankle pulse wave velocity was significantly associated with intracranial arterial stenosis (P = .027, odds ratio = 1.82; 95% confidence interval: 1.07-3.10). The patients with the top decile of brachial-ankle pulse wave velocity showed 56% higher risk for the presence of intracranial arterial stenosis to the whole population, which was more significant in patients younger than 65 years old. We also found that brachial-ankle pulse wave velocity related to both intracranial arterial stenosis and homocysteine.

Conclusion

Our study showed the association of brachial-ankle pulse wave velocity with asymptomatic intracranial arterial stenosis in hypertension patients, especially in relative younger subjects. Brachial-ankle pulse wave velocity might be a relatively simple and repeatable measurement to detect hypertension patients in high risk of intracranial arterial stenosis.