Quantitative proteomics identifies myoferlin as a novel regulator of A Disintegrin and Metalloproteinase 12 in HeLa cells
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- 作者：Yanqing Zhoua ; Lipeng Xionga ; Yang Zhanga ; Rong Yub ; Xiaogang Jianga ; Guoqiang Xua ; c ; gux2002@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADAM12 ; E-cadherin ; Label-free ; Myoferlin ; Quantitative proteomics ; Spectral counting
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：94-104
- 全文大小：1624 K
文摘
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Quantitative proteomics identifies 28 ADAM12-interacting proteins in HeLa cells.
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Myoferlin interacts with and increases the stability of the premature ADAM12.
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Myoferlin upregulates both the premature and mature ADAM12 protein level.
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Myoferlin increases the enzymatic activity of ADAM12.