CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways
详细信息 查看全文
- 作者：Li Zhanga ; 1 ; Lianyong Liub ; c ; 1 ; Xiaohua Hed ; Yunling Shend ; Xuerong Liud ; Jing Weid ; Fang Yud ; Jianqing Tiand ; jianqing0991@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CHIP ; Thyroid cancer ; Proliferation ; MAPK pathway ; AKT pathway
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：26 August 2016
- 年：2016
- 卷：477
- 期：3
- 页码：356-362
- 全文大小：1873 K
文摘
- •
CHIP is significantly upregulated in thyroid cancer cells.
- •
Overexpression of CHIP facilitates proliferation and tumorigenesis of thyroid cancer cells.
- •
Silencing of CHIP inhibits the proliferation and tumorigenesis of thyroid cancer cells.
- •
CHIP promotes thyroid cancer cell proliferation via activating the MAPK and AKT pathways.