HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma
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- 作者：Zhihao Wanga ; b ; Pengchao Hub ; Fang Tanga ; Haiwei Lianc ; Xiong Chenb ; Yingying Zhangb ; Xiaohua Heb ; Wanhong Liub ; liuwanhong@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Conghua Xiea ; chxie_65@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HDAC6 ; Glioblastoma ; EGFR ; Temozolomide
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 August 2016
- 年：2016
- 卷：379
- 期：1
- 页码：134-142
- 全文大小：3366 K
文摘
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HDAC6 is overexpressed in glioblastoma tissues and cell lines.
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HDAC6 promotes cell proliferation and spheroid formation of glioblastoma cells.
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HDAC6 confers resistance to temozolomide (TMZ).
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HDAC6 inhibitors sensitize glioblastoma cells to TMZ.
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HDAC6 confers resistance to TMZ partly via stabilization and activation of EGFR.