The expression and function of E3 ligase SIAH2 in acute T lymphoblastic leukemia
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- 作者：Hongxia Chena ; c ; d ; Ning Wanga ; c ; d ; Guicun Yanga ; b ; c ; d ; Yuxia Guoa ; b ; c ; d ; Yali Shena ; b ; c ; d ; Xiaojing Wanga ; c ; d ; Ping Zhanga ; c ; d ; Youhua Xua ; b ; c ; d ; feiyujidian@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：T-ALL ; SIAH2 ; PHD ; HIF-1α
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：28-36
- 全文大小：963 K
文摘
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The expression of SIAH2 in primary T-ALL patients is significantly higher than ITP patients.
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SIAH2 is significantly associated with the extramedullary infiltration, especially with the mediastinal lymph node metastasis and the pleural effusion.
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SIAH2 knockdown leads to increased apoptosis and decreased proliferation, migration and invasion in Jurkat cells.