- 作者：Yi Feng ; Zili You ; Shuo Yan ; Gang He ; Yubo Chen ; Xiaojun Gou ; Cheng Peng
- 关键词：Antidepressant ; Salvianolic acid B ; Salvia miltiorrhiza ; Forced swimming test ; Tail suspension test
- 刊名：Life Sciences
- 出版年：2012
- 出版时间：27 June, 2012
- 年：2012
- 卷：90
- 期：25-26
- 页码：1010-1014
- 全文大小：488 K
Aims
Salvianolic acid B (SalB), one of the most abundant and bioactive compounds extracted from Salvia miltiorrhiza (Danshen), shows neuroprotective and anti-inflammatory activities in vivo and in vitro. This research was intended to investigate the antidepressant effect of SalB by forced swimming test (FST) and tail suspension test (TST).Main methods
SalB was extracted from S. miltiorrhiza roots and followed by HPLC analysis. Thirty five male C57BL/6 mice were divided into five groups: three SalB groups of different doses, one imipramine group, and one control group. The SalB groups received intraperitoneally (i.p.) 5 mg/kg SalB, 10 mg/kg SalB, and 20 mg/kg SalB respectively. At the same time, the imipramine group received 20 mg/kg imipramine, and the control group saline only. The behavioral tests including FST, TST and locomotor activity test were done after administration of drugs for consecutively three times, at 24, 1, and 0.5 h before the tests.
Key findings
SalB, from S. miltiorrhiza with purity of 95 % , significantly reduced the immobility time in both the FST and TST tests (doses at 5, 10, 20 mg/kg, i.p.), without changing locomotion in spontaneous motor activity.
Significance
This data suggests that besides neuroprotective and anti-inflammatory activities, SalB has promising therapeutic potential in treatment of depressive disorders.