Dioscin raised MTX concentration by inhibiting MDR1 in Caco-2 cells.
Dioscin suppresses MDR1 by inhibiting NF-魏B signaling pathway in Caco-2 cells.
Dioscin can enhance MTX absorption via inhibiting MDR1 in vivo and in vitro.
Dioscin did not increase MTX-induced gastrointestinal mucosal toxicity.