Connective tissue growth factor mediates growth differentiation factor 8-induced increase of lysyl oxidase activity in human granulosa-lutein cells
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- 作者：Hsun-Ming Changa ; Ying Fanga ; b ; Pang-Pin Liua ; c ; Jung-Chien Chenga ; Xiaokui Yangb ; Peter C.K. Leunga ; peter.leung@ubc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：GDF8 ; LOX ; CTGF ; Human granulosa cell
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：434
- 期：Complete
- 页码：186-198
- 全文大小：2293 K
文摘
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GDF8 up-regulates CTGF expression and secretion.
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GDF8 up-regulates LOX expression and increases LOX activity.
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CTGF mediates the GDF8-induced increases in LOX expression and activity.
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ALK5 and SMAD2/SMAD3-SMAD4 are involved in the GDF8-induced up-regulation of CTGF.
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SMAD3 binds to the CTGF promoter.