GDF8 up-regulates CTGF expression and secretion.
GDF8 up-regulates LOX expression and increases LOX activity.
CTGF mediates the GDF8-induced increases in LOX expression and activity.
ALK5 and SMAD2/SMAD3-SMAD4 are involved in the GDF8-induced up-regulation of CTGF.
SMAD3 binds to the CTGF promoter.