Infection of human uterine fibroblasts by Zika virus in vitro: implications for viral transmission in women
详细信息 查看全文
- 作者：Joseph C. Chen ; joseph.chen@siemens.com" class="auth_mail" title="E-mail the corresponding author ; Zuguang Wang ; Hong Huang ; Sara H. Weitz ; Aprilgate Wang ; Xiaolei Qiu ; Mark A. Baumeister ; Arejas Uzgiris ; arejas.uzgiris@siemens.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Zika virus ; Uterine fibroblasts ; Heterosexual transmission ; Viral detection ; Women's health
- 刊名：International Journal of Infectious Diseases
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：51
- 期：Complete
- 页码：139-140
- 全文大小：346 K
文摘
- •
Human uterine fibroblasts are susceptible to Zika virus infection.
- •
Both African and Puerto Rican Zika strains can infect human uterine fibroblasts.
- •
A quantitative reverse transcription PCR with primers targeting the envelop regions of the virus was utilized.
- •
Uterine fibroblasts continually produced virus, while maintaining cellular viability over 5 days.
- •
Uterine fibroblasts may be linked with heterosexual transmission of Zika virus in women.