刊名:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
出版年:2017
出版时间:March 2017
年:2017
卷:1862
期:3
页码:337-350
全文大小:3358 K
卷排序:1862
文摘
Hepatic SREBP-2 over-activation and impaired autophagy in NAFLD patients Altering S1P and S2P bioactivity induces autophagy via inhibiting SREBP-2 cleavage. Altering S1P and S2P bioactivity improves macrolipophagy in a cell model of NAFLD. shRNAs targeting S1P or S2P promote autophagy related gene expression in vitro. Knockdown of S1P and S2P improves macrolipophagy in HFD-fed mice.