NF1, Sp1 and HSF1 are synergistically involved in sulfide-induced sqr activation in echiuran worm Urechis unicinctus
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- 作者：Xiaolong Liu ; Zhenkui Qin ; Xueyu Li ; Xiaoyu Ma ; Beibei Gao ; Zhifeng Zhang ; zzfp107@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sulfide ; quinone oxidoreductase (SQR) ; Sulfide ; Urechis unicinctus ; Transcription regulation ; Transcription factor
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：175
- 期：Complete
- 页码：232-240
- 全文大小：1939 K
文摘
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Sulfide activates sqr transcription against respiratory toxicity in Urechis unicinctus.
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Sulfide increases expressions and activities of NF1, Sp1 and HSF1 in a time-dependent manner.
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NF1 and Sp1 participate in both basal and early sulfide-induced sqr transcription.
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HSF1 functions more significantly than NF1 and Sp1 in sulfide-induced sqr transcription.
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Transcription factors NF1, Sp1 and HSF1 enhance sqr promoter activity synergistically.