Global gene expression analysis of peripheral blood mononuclear cells in rhesus monkey infants with CA16 infection-induced HFMD
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- 作者：Jie Song ; Yajie Hu ; Yunguang Hu ; Jingjing Wang ; Xiaolong Zhang ; Lichun Wang ; Lei Guo ; Yancui Wang ; Ruotong Ning ; Yun Liao ; Ying Zhang ; Huiwen Zheng ; Haijing Shi ; Zhanlong He ; Qihan Li ; liqihan@imbcams.com.cn" class="auth_mail" title="E-mail the corresponding author ; Longding Liu ; longdingl@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Coxsackievirus A16 (CA16) ; Global gene expression analysis ; Peripheral blood mononuclear cells ; Rhesus monkey infants
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 March 2016
- 年：2016
- 卷：214
- 期：Complete
- 页码：1-10
- 全文大小：2402 K
文摘
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The first global gene expression analysis of peripheral blood mononuclear cells in rhesus monkey infants with CA16 infection-induced HFMD (hand, foot, and mouth disease).
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Nine hundred and forty-eight significantly differentially expressed genes were identified that were associated with 5 gene ontology categories, including cell communication, cell cycle, immune system process, regulation of transcription and metabolic process.
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To confirm the results obtained from microarray analysis, 16 of the differentially expressed genes were chosen for qRT-PCR validation.