The first global gene expression analysis of peripheral blood mononuclear cells in rhesus monkey infants with CA16 infection-induced HFMD (hand, foot, and mouth disease).
Nine hundred and forty-eight significantly differentially expressed genes were identified that were associated with 5 gene ontology categories, including cell communication, cell cycle, immune system process, regulation of transcription and metabolic process.
To confirm the results obtained from microarray analysis, 16 of the differentially expressed genes were chosen for qRT-PCR validation.