Valsartan ameliorates KIR2.1 in rats with myocardial infarction via the NF-κB-miR-16 pathway
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- 作者：Xinran Lia ; 1 ; Hesheng Hub ; Ye Wangb ; Mei Xueb ; Xiaolu Lib ; Wenjuan Chengb ; 1 ; Yongli Xuana ; Jie Yina ; Na Yanga ; Suhua Yanb ; yansuhua296@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MI ; myocardial infarction ; APD ; action potential duration ; miRNAs ; microRNAs ; ARB ; AT1 receptor blocker ; AMI ; acute myocardial infarction ; ChIP ; Chromatin immunoprecipitation ; EF ; ejection fraction ; CO ; cardiac output ; HR ; heart rate ; LVEDP ; LV end-diastolic pressure ; LVESP ; LV end-systolic pressure ; dP/dtmax ; the maximal rates of increase in left ventricular pressure ; dP/dtmin ; the maximal rates of decrease in left ventricular pressure
- 刊名：Gene
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：590
- 期：2
- 页码：201-209
- 全文大小：1025 K
文摘
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We focused on miR-16, a cardiac muscle enriched miRNA received less attention.
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We confirmed that miR-16 is a direct regulator of Kir2.1 for the first time.
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Valsartan protects Kir2.1 protein possibly via the mechanism of NF-kB-mir16.