β-arrestin1 initiates EMT and promotes the migration and invasion of prostate cancer cells.
β-arrestin1 could increase the activity and expression of β-catenin.
β-arrestin1 inhibits GSK-3β activity through modulating the activities of Akt and PP2A.
β-arrestin1 functions as a key scaffold protein in modulating GSK-3β/β-catenin signaling.
Duan and Guohua Zeng designed research; Duan, Zhang, Kong, Mai, Lan and Chen performed research; Cai, Deng and Zhiwen Zeng analyzed data; Duan and Wu wrote the paper.