O-GlcNAcylation of the Signaling Scaffold Protein, GNB2L1 Promotes its Degradation and Increases Metastasis of Gastric Tumours
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- 作者：Shimeng Cheng ; Jie Ren ; Lina Su ; Jianlan Liu ; Qingmei Liu ; Jing Zhou ; Xiaolu Ye ; Ningwen Zhu ; zhuningwen@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：O-GlcNAcylation ; GNB2L1 ; Degradation ; Gastric cancer ; Metastasis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：478
- 期：4
- 页码：1497-1502
- 全文大小：1118 K
文摘
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GNB2L1 is modified by OGT and the O-GlcNAcylation level on GNB2L1 in gastric cancer depends on OGT expression.
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The O-GlcNAcylation on GNB2L1 reverses the inhibition of GNB2L1 on gastric cancer metastasis.
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GNB2L1 protein levels is negatively correlated with OGT expression.
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The O-GlcNAcylation on GNB2L1 regulates the stability of GNB2L1.