Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
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- 作者：Weifei Zhu1 ; 7 ; Jill C. Gregory1 ; 7 ; Elin Org2 ; Jennifer A. Buffa1 ; Nilaksh Gupta1 ; Zeneng Wang1 ; Lin Li1 ; Xiaoming Fu1 ; Yuping Wu5 ; Margarete Mehrabian2 ; R. Balfour Sartor3 ; Thomas M. McIntyre1 ; Roy L. Silverstein4 ; W.H. Wilson Tang1 ; 6 ; Joseph A. DiDonato1 ; J. Mark Brown1 ; Aldons J. Lusis2 ; Stanley L. Hazen1 ; 6 ; hazens@ccf.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：24 March 2016
- 年：2016
- 卷：165
- 期：1
- 页码：111-124
- 全文大小：4080 K
文摘
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Elevated TMAO levels predict incident risk for thrombotic events in human subjects
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TMAO enhances sub-maximal stimulus-dependent platelet activation
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Dietary choline, gut microbes, and TMAO are linked to thrombotic potential in vivo
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Microbial transplantation shows that thrombosis potential is a transmissible trait