Campyridones A-D, pyridone alkaloids from a mangrove endophytic fungus Campylocarpon sp. HDN13-307

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• 作者：Meilin Zhu ; Xiaomin Zhang ; Huimin Feng ; Qian Che ; Tianjiao Zhu ; Qianqun Gu ; Dehai Li ; ^{dehaili@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pyridone alkaloids ; Endophytic fungus ; Mangrove plant ; Campylocarpon sp. ; Cytotoxicity
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：15 September 2016
• 年：2016
• 卷：72
• 期：37
• 页码：5679-5683
• 全文大小：838 K

文摘

Two pairs of epimers, campyridones A and B (1 and 2) and campyridones C and D (3 and 4), were isolated from the mangrove endophytic fungus Campylocarpon sp. HDN13-307, as well as the biogenetically related known ilicicolin H (5). Their structures including absolute configurations were elucidated on the basis of the spectroscopic analysis and ECD calculations. The new compounds 1–4 possess unprecedented ring systems featured by the appearance of an additional spiro-furanone (1/2) or γ-pyrone (3/4) moieties (C ring), which represents a new family of 4-hydroxy-2-pyridone alkaloids. Compounds 4 and 5 were cytotoxic against Hela cell with IC₅₀ values of 8.8 μM and 4.7 μM, respectively. A plausible biosynthetic pathway for 1–4 is also elucidated.