Modeling and optimization of two phase system for recycling high-speed counter-current chromatographic separation of ketoconazole enantiomers
详细信息 查看全文
- 作者：Panliang Zhanga ; Na Xieb ; Kewen Tanga ; tangkewen@sina.com" class="auth_mail" title="E-mail the corresponding author ; Xiaoming Chenb ; Weifeng Xua ; lotus8870@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HSCCC ; high-speed counter-current chromatography ; CS ; chiral selector ; HP-β-CD ; hydroxypropyl-β-cyclodextrin ; He-β-CD ; hydroxyethyl-β-cyclodextrin ; Me-β-CD ; methyl-β-cyclodextrin ; SBE-β-CD ; sulfobutyl ether-β-cyclodextrin
- 刊名：Separation and Purification Technology
- 出版年：2016
- 出版时间：30 May 2016
- 年：2016
- 卷：164
- 期：Complete
- 页码：41-48
- 全文大小：1835 K
文摘
- •
Ketoconazole enantiomers are separated by recycling HSCCC for the first time.
- •
Model predictions are employed for optimization of the two-phase system.
- •
Method may be extended to the separation of the other racemate.