Immunosuppressive chalcone-isoflavonoid dimers from Campylotropis hirtella

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• 作者：Xiaoping Li^b ; ^&dagger ; ; Congcong Li^b ; ^&dagger ; ; Bixia Xuan^b ; ^&dagger ; ; Xing Du^b ; Li Xia^a ; Zhengwu Shen^a ; ^{Jeff_shen_1999@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Biflavonoids ; Chalcone-isoflavonoid dimer ; Campylotropis hirtella ; Immunosuppressive ; Isoflavonoid
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：12 May 2016
• 年：2016
• 卷：72
• 期：19
• 页码：2464-2471
• 全文大小：469 K

文摘

Twelve new chalcone-isoflavonoid dimers were isolated from the roots of Campylotropis hirtella. The structures of these compounds were elucidated by NMR analysis, while the absolute configurations were determined from the CD spectra. We measured immunosuppressive activities of these compounds on splenic lymphocytes and found that many of the compounds displayed immunosuppressive activities. Compound 8 was the most active, with IC₅₀ values of 3.68 μM for T lymphocyte suppression and 1.79 μM for B lymphocyte suppression.