Melatonin pretreatment prevents isoflurane-induced cognitive dysfunction by modulating sleep-wake rhythm in mice
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- 作者：Tianjiao Xia1 ; annextj@126.com" class="auth_mail" title="E-mail the corresponding author ; Yin Cui1 ; cuiyin1030@163.com" class="auth_mail" title="E-mail the corresponding author ; Shuaishuai Chu chuss0807@163.com" class="auth_mail" title="E-mail the corresponding author ; Jia Song 1030121845@qq.com" class="auth_mail" title="E-mail the corresponding author ; Yue Qian money890713moon@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhengliang Ma ; mazhengliang1964@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaoping Gu ; 13813996903@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sleep&ndash ; wake rhythm ; Isoflurane ; Cognitive ; Melatonin ; NR2B ; CREB
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：1634
- 期：Complete
- 页码：12-20
- 全文大小：2600 K
文摘
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Sleep–wake dysrhythmia is involved in the isoflurane-induced cognition impairment.
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Melatonin has a positive effect on circadian normalization and cognition reversal.
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NR2B–CREB signaling pathway participate in isoflurane-induced cognition impairment.