Integrating candidate metabolites and biochemical factors to elucidate the action mechanism of Xue-sai-tong injection based on 1H NMR metabolomics
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- 作者：Miaomiao Jianga ; Xiaoping Zhaob ; zhaoxiaoping@zcmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Linli Wangc ; Lei Xua ; Yan Zhanga ; Zheng Lia ; lizheng1@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Metabolomics ; NMR ; Non-target ; Cardioprotection ; Pyruvate
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1026
- 期：Complete
- 页码：87-96
- 全文大小：2625 K
文摘
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NMR-based metabolomics approach was used to elucidate the cardioprotective mechanisms of XST.
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XST modulates the metabolic changes caused by I/R injury in three energy metabolism related pathways.
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Pearson correlation was used to interpret the biological functions of candidate metabolites.
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Elevated pyruvate was found as an essential metabolic response of XST treatment.
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XST removes ROS to restore the TCA cycle activity and achieve therapeutic effects.