Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin

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• 作者：Songlin Li ; MD^a ; ¹ ; Chunshu Fang ; MS^a ; ¹ ; Jingqing Zhang ; PhD^b ; Bilin Liu ; MS^b ; Zhuanqin Wei ; MS^a ; Xiaoqing Fan ; BS^a ; Zheng Sui ; MS^a ; Qunyou Tan ; PhD ; MD^a ; ^{tanqy001@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Catanionic lipid nanosystems ; Curcumin ; Bioavailabilities ; Anti-lung cancer activity ; Signaling pathway
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：12
• 期：6
• 页码：1567-1579
• 全文大小：2016 K

文摘

Novel catanionic lipid nanosystems (CLNs) incorporating curcumin (CCM) were developed, and improvements in pharmacokinetics and enhanced anti-lung cancer activity were observed. CCM was present in a lipid matrix surrounded by cationic, anionic and zwitterionic surfactants, forming the core-shell nanosystems. Compared with free CCM, the CCM-CLNs had much higher oral and intravenous bioavailabilities due to enhanced absorption and reduced clearance. The CCM-CLNs exhibited greater cytotoxicity in Lewis lung cancer (LLC) cells, which might have been due to increased antiproliferative, proapoptotic and anti-invasive activities and induction of cell cycle arrest. The CCM-CLNs increased the antitumor efficacy of CCM and decreased the tumor growth rate in tumor-bearing mice. This is the first report of induction of apoptosis in LLC cells by CCM through the PI3K/Akt/FoxO1/Bim signaling pathway. Catanionic lipid nanocarriers show promise for the therapeutic delivery of insoluble anti-tumor drugs.