The regulatory roles of non-coding RNAs in nerve injury and regeneration
详细信息 查看全文
- 作者：Bin Yu ; Songlin Zhou ; Sheng Yi ; Xiaosong Gu ; nervegu@ntu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABI ; acquired brain injury ; BDNF ; brain-derived neurotrophic factor ; CNTF ; ciliary neurotrophic factor ; CNS ; central nervous system ; DRG ; dorsal root gangalion ; IL-6 ; interleukin 6 ; IPA ; ingenuity pathway analysis ; lincRNAs ; large intergenic non-coding RNAs ; lncRNAs ; long non-coding RNAs ; miRNAs (miRs) ; microRNAs ; ncRNAs ; non-coding RNAs ; NGF ; nerve growth factor ; NT-3 ; neurotrophin-3 ; NT-4 ; neurotrophin-4 ; piRNAs ; PIWI-interacting RNAs ; piRNAs ; PIWI-interacting RNAs ; PNS ; peripheral nervous sys
- 刊名：Progress in Neurobiology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：134
- 期：Complete
- 页码：122-139
- 全文大小：2134 K
文摘
- •
ncRNAs, mainly miRNAs and lncRNAs, are dysregulated after CNS and PNS injury.
- •
miRNAs regulate post-nerve-injury changes by binding to target mRNAs to inhibit translation or cause degradation.
- •
Systems-level analysis using IPA helps elucidate the mechanisms underlying ncRNA regulation in nerve regeneration.