miR-223 is upregulated in monocytes from patients with tuberculosis and regulates function of monocyte-derived macrophages
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- 作者：Yanhua Liu ; Ruo Wang ; Jing Jiang ; Bingfen Yang ; Zhihong Cao ; Xiaoxing Cheng ; xcheng2@139.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tuberculosis ; microRNA-223 ; Macrophages
- 刊名：Molecular Immunology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：67
- 期：2
- 页码：475-481
- 全文大小：1578 K
文摘
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Activation and cytokine production in MDM from patients with TB was impaired.
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miR-223 expression was elevated in monocytes and MDM from patients with TB.
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miR-223 could regulate MDM function by inhibition of cytokine production.
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miR-223 modulated activation of NF-κB by inhibition of p65 phosphorylation.