Purification, characterization and in vitro anticoagulant activity of polysaccharides from Gentiana scabra Bunge roots
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- 作者：Weirong Cai ; caiweirong0781@163.com" class="auth_mail" title="E-mail the corresponding author ; Huiling Xu ; Liangliang Xie ; Jian Sun ; Taotao Sun ; Xiaoyan Wu ; Qinbao Fu
- 关键词：Gentiana scabra Bunge ; Polysaccharides ; Purification ; Characterization ; Anticoagulant activity
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 April 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：308-313
- 全文大小：706 K
文摘
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Resin methods were employed to remove the proteins and pigments from polysaccharides of Gentiana scabra Bunge roots.
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The weight-average molecular weights of purified polysaccharides (named GSP-2 and GSP-3) were analyzed by HPGPC.
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Monosaccharide compositions of polysaccharide fractions were measured by HPAEC-PAD.
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GSP-3 showed significant anticoagulant activity in APTT and TT assays.