Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease
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- 作者：Tingting Zhoua ; 1 ; Guo Zub ; 1 ; Xiaogang Zhangc ; Xi Wangc ; Shao Lic ; Xiaoyang Gongd ; Zhanhua Lianga ; zhanhualiangdl@163.com" class="auth_mail" title="E-mail the corresponding author ; Jie Zhaoc ; dlzhaoj@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson's disease ; Neurodegeneration ; Neuroprotection ; Ginsenoside Rg1 ; Wnt/β-catenin signaling pathway
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：480-489
- 全文大小：2240 K
文摘
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Ginsenoside Rg1 ameliorated the behavioral deficits of PD mice model.
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Dopaminergic cell loss reduced with ginsenoside Rg1 treatment in vivo.
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Cell viability was increased by ginsenoside Rg1 pretreatment.
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Ginsenoside Rg1 pretreatment decreased cell apoptosis.
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The neuroprotective effects of ginsenoside Rg1 are exerted through the Wnt/β-catenin signaling pathway.