The rs767649 polymorphism in the promoter of miR-155 contributes to the decreased risk for cervical cancer in a Chinese population
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- 作者：Shizhi Wanga ; 1 ; shizhiwang2009@seu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaoli Caob ; Bo Dingc ; Jinfeng Chend ; Mengjing Cuia ; Yuling Xua ; Xiaoyun Lue ; Zhengdong Zhangf ; g ; Aiqin Hed ; Hua Jinb ; 1 ; ntmgjh@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CC ; cervical cancer ; CSCC ; cervical squamous cell carcinoma ; CESC ; cervical squamous cell carcinoma and endocervical adenocarcinoma ; CI ; confidence interval ; EMT ; epithelial-mesenchymal transition ; GEO ; Gene Expression Omnibus ; miRNA ; microRNA ; OR ; odds ratios ; SNP ; single nucleotide polymorphism ; TCGA ; The Cancer Genome Atlas
- 刊名：Gene
- 出版年：2016
- 出版时间：20 December 2016
- 年：2016
- 卷：595
- 期：1
- 页码：109-114
- 全文大小：374 K
文摘
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The study first analyzed the association of rs767649 with cervical cancer risk
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The association was determined through a two-stage case-control study with 1157 cases and 1280 controls
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The rs767649 linked to reduced risk of CC, especially among the women older than 49 years or women at menopause.
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Transition of rs767649 A to T allele lead to miR[HYPHEN]155 downregulation, which may contribute to decreased risk of CC.