Intestinal mucosal immune response in ducklings following oral immunisation with an attenuated Duck enteritis virus vaccine
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- 作者：Xiaoyan Yang ; Xuefeng Qi ; Anchun Cheng ; Mingshu Wang ; Dekang Zhu ; Renyong Jia ; Xiaoyue Chen
- 关键词：Duck enteritis virus (DEV) ; Intestinal mucosal immune response ; Oral inoculation
- 刊名：The Veterinary Journal
- 出版年：2010
- 出版时间：August 2010
- 年：2010
- 卷：185
- 期：2
- 页码：199-203
- 全文大小：1030 K
文摘
To investigate the intestinal mucosal immune responses in ducklings orally inoculated with attenuated Duck enteritis virus (DEV), the kinetics of the viral load, the specific humoral immune responses, and the distribution of immunoglobulin (Ig)A-secreting cells in the intestine were evaluated. Oral inoculation with attenuated DEV stimulated an IgA-dominant response in intestinal secretions and a IgY-dominant response in the serum. The dramatic increase in virus-specific mucosal IgA 15 days after inoculation was accompanied by reductions in the DEV intestinal load, suggesting that the IgA response has a role in controlling viral replication. The kinetics of virus-specific IgA production closely correlated with the presence of IgA+ plasma cells in the intestinal lamina propria.