Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity

详细信息    查看全文

• 作者：Xiaoyun Lu^a ; ^b ; ¹ ; ^{luxy2016@jnu.edu.cn} ; Jian Tang^b ; ^c ; ¹ ; Shengyang Cui^b ; ^c ; Baojie Wan^d ; Scott G. Franzblauc^d ; Tianyu Zhang^b ; Xiantao Zhang^e ; Ke Ding^a ; ^b
• 关键词：Anti-tubercular ; Hybrid ; Mtb ; Pyrazolo[1 ; 5-a]pyridine-3-carboxamide
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：41-48
• 全文大小：902 K
• 卷排序：125

文摘

Emergence of MDR-TB and XDR-TB. Pyrazolo[1,5-a]pyridine-3-carboxamide incorporated with fragment of clinical anti-TB drugs. Hybrid 7 exhibited activities against H37Rv and resistant Mtb strains with MIC values of 0.006 and 0.003–0.014 μg/mL.