Regulation of Neurospora Catalase-3 by global heterochromatin formation and its proximal heterochromatin region
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- 作者：Yajun Wanga ; 1 ; Qing Donga ; 1 ; Zhaolan Dinga ; Kexin Gaia ; Xiaoyun Hanb ; Farah Naz Kaleria ; Qun Hea ; Ying Wanga ; wangying@cau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CAT ; catalase ; H2O2 ; hydrogen peroxide ; NOX ; NADPH oxidase ; O2&bull ; &minus ; superoxide ; ROS ; reactive oxygen species ; dim-5 ; defective in methylation-5 ; hpo ; heterochromatin protein ; ChIP-qPCR ; chromatin immunoprecipitation assay-quantitative polymerase chain reaction ; GST ; Glutathione S-transferase
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：139-152
- 全文大小：7841 K
文摘
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cat-3 promoter is adjacent with 5-kb AT-rich DNA sequence which forms heterochromatin.
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CAT-3 levels were increased in heterochromatin defective mutants, such as dim-5KO.
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H3ac levels were associated with positive transcription of cat-3 gene.
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cat-3Δ5 and global heterochromatin defection synthetically regulate cat-3 expression.
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The smear of CAT-3 in heterochromatin mutants might be associated with modifications.