Aza-Payne rearrangement of α,α-disubstituted-aziridinemethanols

详细信息    查看全文

• 作者：Feng Xichun ; Qiu Guofu ; Liang Shucai ; Teng Hanbing ; Wu Lamei and Hu Xianming
• 刊名：Tetrahedron: Asymmetry
• 出版年：2006
• 出版时间：15 May 2006
• 年：2006
• 卷：17
• 期：9
• 页码：1394-1401
• 全文大小：188 K

文摘

The aza-Payne rearrangement of activated N-Ts-α,α-disubstituted-aziridinemethanols, induced by NaOH in the mixed solvent ^tBuOH/H₂O/THF (4:5:1) or NaH in a mixed solvent of THF/HMPA (10:1), as well as some N-Boc-α,α-disubstituted-aziridinemethanols with the latter reagent/solvent combination, provides the corresponding epoxides in up to 99 % yield.