AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis
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- 作者：Yu-gang Wanga ; Xin-hua Qua ; Ying Yanga ; Xiu-guo Hana ; Lei Wanga ; Han Qiaoa ; Qi-ming Fana ; chillow@163.com" class="auth_mail" title="E-mail the corresponding author ; Ting-ting Tanga ; tingtingtang@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Ke-rong Daia ; b ; krdai@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BMSC ; bone marrow stromal cell ; AMPK ; AMP-activated protein kinase ; OPN ; osteopontin ; Gfi1 ; growth factor independence-1 ; Runx2 ; runt-related transcription factor 2 ; Osx ; Osterix ; ALP ; alkaline phosphatase ; BSP ; bone sialoprotein ; OC ; osteocalcin ; PPARγ ; peroxisome proliferator activated receptor-γ ; C/EBP ; CAAT/enhancer binding protein ; aP2 ; adipocyte Protein 2 ; GLUT4 ; glucose transporter 4 ; AICAR ; 5-Aminoimidazole-4-carboxamide ribonucleoside ; ACC ; acetyl-CoA carboxylase ; GS ; glycogen synthase
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1270-1282
- 全文大小：2446 K
文摘
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AMPK hyperactivation stimulated osteogenesis and inhibited adipogenesis.
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OPN mediated AMPK regulation of osteogenesis and adipogenesis.
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AMPK activates OPN expression through Gfi1.
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AMPK enhanced in vivo ectopic bone formation through the AMPK-Gfi1-OPN axis.