Association of DYRK1A polymorphisms with sporadic Parkinson’s disease in Chinese Han population
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- 作者：Luan Cena ; b ; 1 ; Yousheng Xiaoa ; b ; 1 ; Lei Weia ; c ; Mingshu Moa ; d ; Xiang Chena ; Shaomin Lie ; Xingling Yangf ; xinlingyang163@163.com" class="auth_mail" title="E-mail the corresponding author ; Qinghui Huangd ; Shaogang Qug ; Zhong Peia ; Pingyi Xua ; d ; pingyixu@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PD ; Parkinson&rsquo ; s disease ; Dyrk1A ; dual-specificity tyrosine phosphorylation-regulated kinase 1A ; SNPs ; single nucleotide polymorphism ; DA ; dopamine ; LBs ; Lewy bodies ; AD ; Alzheimer&rsquo ; s disease ; HC ; health control ; NMS ; none motor syndrome ; UPDRS III ; Unified Parkinson's Disease Rating Scale III ; CI ; confidence interval ; HWE ; Hardy-Weinberg equilibrium ; OR ; odds ratio ; PCR ; polymerase chain reaction ; SD ; standard deviation
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：632
- 期：Complete
- 页码：39-43
- 全文大小：528 K
文摘
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α-Synuclein aggregation in Lewy Bodies is a pathological hallmark of PD.
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DYRK1A phosphorylates α-synuclein and enhances its neurotoxicity to DA neurons.
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We investigated the genetic variation of DYRK1A in sporadic Chinese PD patients.
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TT genotype of rs8126696 is a potential risk factor of PD in Chinese Han population.