Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family
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- 作者：Eriona Hysolli1 ; 8 ; Yoshiaki Tanaka1 ; 8 ; Juan Su1 ; 2 ; Kun-Yong Kim1 ; Tianyu Zhong1 ; 3 ; Ralf Janknecht4 ; Xiao-Ling Zhou1 ; 5 ; Lin Geng1 ; Caihong Qiu1 ; Xinghua Pan1 ; Yong-Wook Jung1 ; 6 ; Jijun Cheng1 ; Jun Lu1 ; Mei Zhong7 ; Sherman M. Weissman1 ; In-Hyun Park1 ; inhyun.park@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：12 July 2016
- 年：2016
- 卷：7
- 期：1
- 页码：43-54
- 全文大小：2998 K
文摘
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Depletion of the miR-29a family improves reprogramming efficiency
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DNA demethylation is a major change induced by miR-29a depletion
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Methylation at the CpG island shore is highly regulated by the miR-29a family
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iPSC derived by depletion of the miR-29a family is epigenetically close to ESCs