The role of the orphan G protein-coupled receptor 37 (GPR37) in multiple myeloma cells

详细信息    查看全文

• 作者：Xianting Huang ; Yuchan Wang ; Xun Nan ; Song He ; Xiaohong Xu ; Xinghua Zhu ; Jie Tang ; Xiaojing Yang ; Li Yao ; Xinxiu Wang ; Chun Cheng
• 关键词：GPR37 ; CAM-DR ; PI3K/Akt ; MAPK/ERK ; Proliferation
• 刊名：Leukemia Research
• 出版年：February, 2014
• 年：2014
• 卷：38
• 期：2
• 页码：225-235
• 全文大小：3124 K

文摘

The orphan G protein-coupled receptor 37 (GPR37) is homologous to endothelin (ETB-R) and bombesin (GRP-R, NMB-R) receptors. The present study was undertaken to determine the expression and functional significance of GPR37 in human multiple myeloma (MM). We found that GPR37 was lowly expressed in MM cell adhesion model and highly expressed in proliferating cells. In vitro, meddling with the expression of GPR37 affected the CAM-DR by regulating the ability of cell adhesion and the activity of Akt and ERK in MM cells. Further studies indicated the positive role of GPR37 in the proliferation of MM cells.