Synthesis, biological evaluation, and molecular dynamics (MD) simulation studies of three novel F-18 labeled and focal adhesion kinase (FAK) targeted 5-bromo pyrimidines as radiotracers for tumor
This was the first attempt to develop the FAK targeted tumor diagnostic imaging agents on the radiopharmaceutical level. Coronal micro-PET/CT images of a mouse bearing S180 tumor confirmed that [18F]2 could be accumulated in tumor. The results of the molecular dynamics simulations consists with the changing trends of the interaction between F-19 standards and the FAK.