Selection and antitumor activity of anti-Bcl-2 DNAzymes
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- 作者：Xinhui Yanga ; Zhi Lia ; b ; Lu Zhanga ; b ; Jiang Hea ; b ; Lun-Quan Suna ; b ; lunquansun@csu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNAzyme ; Bcl-2 ; Apoptosis ; Chemoresistance
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：479
- 期：3
- 页码：544-550
- 全文大小：1160 K
文摘
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Generated anti-BCL-2 DNAzymes in a multiplex selection system.
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Demonstrated 3′-inversion as an efficient way to modify the DNAzyme.
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Validated the roles of anti-BCL-2 DNAzymes in chemosensitization of cancer.