Simultaneous determination of eleven compounds related to metabolism of bioamines in rat cortex and hippocampus by HPLC-ECD with boron-doped diamond working electrode
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- 作者：Lu Zhang ; Jun-qing Yang ; Ying Luo ; Jing-chuan Shang ; Xin-hui Jiang ; Jiangxinhui3@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Monoamine ; Amino acid ; Metabolite ; HPLC-ECD ; Cortex ; Hippocampus
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：41-51
- 全文大小：1551 K
文摘
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The BDD (boron-doped diamond) electrode was used as working electrode of electrochemical detector.
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HPLC-ECD method was developed for simultaneous determination of eleven analytes related to metabolism of bioamines in rat brain.
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Vanillic acid was selected as IS for quantification of the eleven analytes.
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The concentrations of the 11 compounds were compared in cortex and hippocampus collected from the same rats.